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Stem cell researchers at the US National Institutes of Health (NIH) have been left frustrated and confused following the demise of the agency’s Center for Regenerative Medicine (CRM). The intramural programme’s director, stem cell biologist Mahendra Rao, left the NIH, in Bethesda, Maryland, on 28March, and the centre’s website was taken down on 4 April. Although no official announcement had been made at the time Nature went to press, NIH officials say that they are rethinking how they will conduct in house stem cell research.

Researchers affiliated with the centre say that they have been left in the dark. When contacted by Nature on 7April, George Daley, a stem cell biologist at Harvard Medical School in Boston, Massachusetts, and a member of the centre’s external advisory board, said that he had not yet been told of Rao’s departure or the centre’s closure.

The CRM was established in 2010 to centralize the NIH’s stem cell programme. Its goal was to develop useful therapies from induced pluripotent stem (iPS) cells adult cells that have been converted into embryonic like stem cells and shepherd them towards clinical trials and regulatory approval. Its budget was intended to be $52million over seven years.

Rao took the helm in 2011. Relations seem to have soured last month owing to an NIH decision to award funding to only one project aiming to move iPS cells into a clinical trial. Rao says he resigned after this became clear. He says that he had hoped that five trials would be funded, especially because the centre had already sorted out complex issues relating to tissue sources, patents and informed consent.

James Anderson, director of the NIH’s Division of Program Coordination, Planning,
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and Strategic Initiatives, which administered the CRM, counters that only one application that made by Kapil Bharti of the National Eye Institute in Bethesda and his colleagues received a high enough score from an external review board to justify continued funding. The team aims to use iPS cells to treat age related macular degeneration of the retina, and hopes to commence human trials within a few years. Several other proposals, which involved the treatment of cardiac disease, cancer and Parkinson’s disease, will not receive funding to ready them for clinical trials. Anderson stresses that Bharti’s trial will not be affected by the CRM’s closure.

Other human iPS cell trials are further along. For example, one on macular degeneration designed by Masayo Takahashi at the RIKEN Center for Developmental Biology in Kobe, Japan, began recruiting patients last August.

Anderson says that the CRM will not continue in its current form. “The field is moving so fast that we need to rethink.” To that end, the NIH plans to hold a workshop in May to gather stem cell researchers together and decide what to do with the programme and its remaining budget. “To me that’s just smart science,” he says. “If something’s not on track you don’t keep spending money on it.”

One option could be to allow CRM projects to be absorbed by the National Center for Advancing Translational Sciences, an NIH institute established in 2011 to translate basic research into therapies. But Anderson says that participants at the workshop will also discuss whether the NIH needs to replace the CRM with another dedicated stem cell programme.

Rao says he is not yet sure what his plans are. He has already joined the boards of two stem cell therapy companies, and eventually hopes to find a company that will allow him to proceed with clinical trials of iPS cell treatments for Parkinson’s disease.

He says that despite what has happened, he is proud of the CRM’s accomplishments: its researchers have generated more than 400 lines of iPS cells, and the centre has funded two contractors to create 12lines of clinical grade iPS cells that will be available later this year. But, he adds,
long timberland boots cell programme closes
“It’s a little disappointing. The NIH is at a stage where it can be a world leader.”

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Anne Kelly, founder and president of JunoActive in Mendota Heights, describes her company as a niche of a niche. It offers plus size activewear for women at higher than average prices. The former catalog business, now online, sells swimwear, activewear, intimates and athletic shoes for women size 14 to 6x. Dresses, suitcoats and blouses have never been part of the mix, despite customers requests. Since she started the company in 1995, Kelly has resisted opening a retail store because the profit margins were better online. But more than a week ago, she opened Juno first foray into bricks and mortar at Mall of America. It on the first floor in the athleisure wing that includes Athleta, Lululemon and Fabletics. Kelly, 64, talked to the Star Tribune about why she decided to open her first retail store when so many apparel stores are closing and even athleisure star Lululemon appears to be lagging.

A: We take a functional approach, so we look at the same fabrics that marathoners use. Fabrics that stretch, reduce chafing and reduce moisture. Our SoftWik collection is very popular. The fabric is so yummy you just want to pet it. We make leggings, capris and T shirts out of it. QuikWik is a heavier fabric that made domestically. We make bottoms and bra tops out of it. We working with an Italian swimwear company on a fabric they use for competitive swimmers. I keep an eye on the high tech market.
long timberland boots Anne Kelly of JunoActive sees opportunity in being contrarian with new MOA store